Which amendment defines federal powers as being limited to those explicitly listed?

The Tenth Amendment is significant because it specifically establishes the principle of federalism, emphasizing that any powers not explicitly granted to the federal government by the Constitution are reserved for the states or the people. This amendment underscores the limited nature of federal authority and serves as a safeguard against an overreach of power by the federal government. It is a crucial component of the constitutional framework, as it delineates the scope of federal powers and affirms the role of states in governance.

The other amendments mentioned do not address the limitation of federal powers in the same way. For example, the First Amendment primarily focuses on individual rights related to freedom of speech, religion, and assembly. The Fifth Amendment deals with rights in legal proceedings, such as protection against self-incrimination and double jeopardy. The Fourteenth Amendment addresses citizenship rights and equal protection under the law but does not limit federal powers in the context described by the Tenth Amendment. Thus, the Tenth Amendment is the most appropriate choice for defining the limitations of federal powers to those explicitly listed in the Constitution.